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This example shows, how to run MS Word, open *.doc file and insert some string to this file, save and close document. Don't forget add ComObj in uses chapter.

uses
  ComObj;
...
var
  Word: Variant;
...
procedure TForm1.Button1Click(Sender: TObject);
begin
  Word:=CreateOLEObject('Word.Application');
  Word.Visible:=True;
  Word.Documents.Open(GetCurrentDir+'\Test.doc');
  Word.WordBasic.Insert('Greatis ');
  Word.Documents.Save;
end;

procedure TForm1.Button2Click(Sender: TObject);
begin
  Word.Documents.Close;
end;